Protein Modification Reagents
Cayman Chemical N- 1-Carboxyethyl-L-lysIn1mg
An advanced glycation end product; protein bound, but not free CEL, binds to RAGE; elevated in the lens of diabetic patients with cataract; decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner at 1 mM
Cayman Chemical TCEP-bIotIn 500ug
An affinity probe for protein lysine crotonylation; addition of the TCEP moiety to crotonylated lysine residues results in adduct formation that allows for detection or immobilization of crotonylated proteins through interaction with the biotin ligand; has been used in the detection and isolation of crotonylated histones in HEK293 cells
Biolegend Cell-Vive™ GMP Recombinant Human FLT3L (carrier-free); Reactivity: Human; Apps: BA; Size: 50 μg
Cell-Vive™ GMP Recombinant Human FLT3L (carrier-free); Reactivity: Human; Apps: BA; Size: 50 μg
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.
- Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
- Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
- Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
- Arrests both HCC827 and H1975 cell lines at G1 phase.
Medchemexpress LLC WDR5 degrader-1 | 3032434-45-7 | 98.00% | 972.98 | 5 MG
WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. It selectively degrades WDR5 over the CRBN neo-substrate IKZF1.
- Cereblon (CRBN)-recruiting degrader
- Selectively degrades WDR5 over IKZF1
Medchemexpress LLC Protac EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | C55H70N12O4S | 5 MG
PROTAC designed to selectively target and induce degradation of mutant forms of the epidermal growth factor receptor (EGFR). Demonstrates potent degradation of EGFRdel19 and EGFRL858R/T790M in cellular assays and inhibits growth of EGFR-driven cancer cell lines. Supplied as a high-purity research reagent with recommended solvent and storage conditions.
- Targets mutant EGFR, inducing degradation of activating and resistance variants.
- Demonstrated cellular potency with low-nanomolar DC50 values.
- High reported purity suitable for biochemical and cellular studies.
- Soluble in DMSO at 100 mg/mL; may require ultrasonic treatment.
- Store protected from light and under inert atmosphere; in solvent: -80°C (6 months), -20°C (1 month).
Cayman Chemical PROTAC CRBN Degrader-1 5mg
A PROTAC that drives CRBN degradation (DC50 = 200 nM in HeLa cells)
![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-folate] | 95.7% | 5000 (average) | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000281640.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-folate] | 95.7% | 5000 (average) | 25 MG
DSPE-PEG-Folate (MW 5000) is a pegylated lipid conjugate in which a DSPE lipid anchor is linked to a poly(ethylene glycol) chain terminated with folic acid. It is supplied as a solid and is formulated for use in liposomes, micelles, and other nanoparticle systems to enable folate receptor-mediated targeting and uptake.
- Provides folate receptor targeting for enhanced cellular uptake.
- Contains a DSPE lipid anchor for stable membrane insertion.
- Uses a PEG 5000 chain to improve circulation and reduce nonspecific clearance.
- High purity supports reproducible nanoparticle formulation.
- Supplied as a solid for convenient storage and handling.
Medchemexpress LLC PROTAC EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 25 MG
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.
- Potently inhibits EZH2 methyltransferase activity (IC50: 2.7 nM).
- Demonstrates anti-proliferative activity against human EOL1, MV4-11, Pfeiffer, RS4-11, and WSUDLCL2 cells.
- Inhibits cell viability in H128-LM, H128-BPM, H128 wildtype, and H128-Mut cells.
- Enhances sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
- Exhibits antitumor activity in H128-LM xenograft mouse models, prolonging survival when combined with Carboplatin, VP16, or VM26.